:root {
  --bg: #f3f6f4;
  --ink: #1c2b24;
  --muted: #5d6f66;
  --line: #c9d5ce;
  --card: #ffffff;
  --accent: #1f6b4a;
  --accent-ink: #fff;
  --warn: #8a3b12;
  --ok: #1f6b4a;
  --fail: #9b1c1c;
  --run: #215a91;
  --font: "IBM Plex Sans", "Noto Sans JP", "Segoe UI", sans-serif;
  --mono: "IBM Plex Mono", "Consolas", monospace;
}

* { box-sizing: border-box; }
body {
  margin: 0;
  font-family: var(--font);
  color: var(--ink);
  background:
    radial-gradient(1200px 500px at 10% -10%, #d9ebe1 0%, transparent 55%),
    linear-gradient(180deg, #eef3f0 0%, var(--bg) 40%);
  min-height: 100vh;
}
a { color: var(--accent); text-decoration: none; }
a:hover { text-decoration: underline; }
.wrap { width: min(1100px, calc(100% - 2rem)); margin: 0 auto; }

.site-header {
  border-bottom: 1px solid var(--line);
  background: rgba(255,255,255,0.85);
  backdrop-filter: blur(8px);
  position: sticky;
  top: 0;
  z-index: 10;
}
.header-inner {
  display: flex;
  align-items: center;
  gap: 1.25rem;
  padding: 0.85rem 0;
}
.brand {
  font-weight: 700;
  letter-spacing: 0.02em;
  color: var(--ink);
  font-size: 1.15rem;
}
nav { display: flex; gap: 1rem; flex: 1; }
.mode-badge {
  font-family: var(--mono);
  font-size: 0.75rem;
  border: 1px solid var(--line);
  border-radius: 999px;
  padding: 0.2rem 0.65rem;
  background: #fff;
  color: var(--muted);
}

main.wrap { padding: 1.75rem 0 3rem; }
.site-footer {
  display: flex;
  justify-content: space-between;
  gap: 1rem;
  padding: 1rem 0 2rem;
  color: var(--muted);
  font-size: 0.85rem;
  border-top: 1px solid var(--line);
}

.hero h1 { margin: 0 0 0.4rem; font-size: 1.8rem; }
.hero p { color: var(--muted); max-width: 40rem; }
.grid-2 {
  display: grid;
  grid-template-columns: 1.2fr 0.8fr;
  gap: 1.5rem;
  margin-top: 2rem;
}
@media (max-width: 800px) {
  .grid-2 { grid-template-columns: 1fr; }
}

h2 { font-size: 1.1rem; margin: 0 0 0.75rem; }
.muted { color: var(--muted); }
code { font-family: var(--mono); font-size: 0.9em; }

.btn {
  display: inline-block;
  background: var(--accent);
  color: var(--accent-ink);
  border: none;
  border-radius: 8px;
  padding: 0.55rem 1rem;
  font-weight: 600;
  cursor: pointer;
}
.btn:hover { filter: brightness(1.05); text-decoration: none; color: var(--accent-ink); }
.btn-secondary {
  background: #fff;
  color: var(--accent);
  border: 1px solid var(--accent);
  margin-left: 0.35rem;
}
.btn-secondary:hover { color: var(--accent); }
.btn-text {
  background: none;
  border: none;
  color: var(--muted);
  cursor: pointer;
  font: inherit;
  padding: 0.2rem 0.4rem;
}
.btn-text:hover { color: var(--ink); }
.tiny { font-size: 0.8rem; margin-left: 0.4rem; }
.run-kick { display: flex; flex-wrap: wrap; gap: 0.75rem; align-items: center; margin: 0.5rem 0 0.75rem; }
.inline-form { display: inline; margin: 0; }
.resume-hint { flex-basis: 100%; margin: 0; font-size: 0.85rem; }


.alert {
  background: #fff1e8;
  border: 1px solid #efc2a5;
  color: var(--warn);
  padding: 0.75rem 1rem;
  border-radius: 8px;
  margin: 1rem 0;
}

.form-card {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 12px;
  padding: 1.25rem;
  display: grid;
  gap: 0.9rem;
  max-width: 28rem;
}
.form-card label {
  display: grid;
  gap: 0.35rem;
  font-size: 0.9rem;
  font-weight: 600;
}
.form-card input:not([type="file"]),
.form-card select {
  font: inherit;
  padding: 0.5rem 0.6rem;
  border: 1px solid var(--line);
  border-radius: 8px;
}
.file-pick-label {
  font-size: 0.9rem;
  font-weight: 600;
  margin: 0;
}
input.fastq-native {
  display: block;
  width: 100%;
  max-width: 100%;
}
.drop-zone {
  border: 2px dashed var(--line);
  border-radius: 10px;
  padding: 1.1rem 0.75rem;
  text-align: center;
  color: var(--muted);
  background: #fafcfb;
}
.drop-zone.is-drag {
  border-color: var(--accent);
  color: var(--accent);
  background: #eef7f2;
}
.upload-panel { margin: 1.5rem 0 2rem; }
.form-wide { max-width: 40rem; }
.ref-block {
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 0.75rem 0.9rem 0.9rem;
  display: grid;
  gap: 0.65rem;
}
.ref-block legend {
  padding: 0 0.35rem;
  font-size: 0.85rem;
  font-weight: 600;
}
.s3-line {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: 0.25rem 0.15rem;
  margin: 0;
  font-size: 0.9rem;
}
.archive-input {
  font: inherit;
  font-family: var(--mono);
  width: 10rem;
  padding: 0.35rem 0.45rem;
  border: 1px solid var(--line);
  border-radius: 6px;
}
.upload-form progress {
  width: 100%;
  height: 0.55rem;
}

table {
  width: 100%;
  border-collapse: collapse;
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 10px;
  overflow: hidden;
}
th, td {
  text-align: left;
  padding: 0.55rem 0.7rem;
  border-bottom: 1px solid var(--line);
  font-size: 0.92rem;
}
th { background: #f7faf8; font-size: 0.8rem; color: var(--muted); }
.ticket-list { list-style: none; padding: 0; margin: 0; }
.ticket-list li {
  padding: 0.45rem 0;
  border-bottom: 1px solid var(--line);
}

.status {
  font-family: var(--mono);
  font-size: 0.78rem;
  padding: 0.15rem 0.45rem;
  border-radius: 999px;
  border: 1px solid var(--line);
}
.status-idle { background: #f3f3f3; color: var(--muted); }
.status-queued { background: #f3f3f3; color: var(--muted); }

.hub-section {
  margin: 2rem 0;
  padding-top: 0.5rem;
  border-top: 1px solid var(--line);
}
.hub-section > h2 { margin-top: 0; }
.btn:disabled {
  opacity: 0.5;
  cursor: not-allowed;
  filter: none;
}
.status-running { background: #e7f0ff; color: #1d4f91; }
.status-succeeded { background: #e5f6ec; color: var(--ok); }
.status-failed { background: #fde8e8; color: var(--fail); }

.status-panel {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 1rem;
  margin: 1rem 0;
}
.log {
  background: #15201b;
  color: #d7e6dd;
  padding: 1rem;
  border-radius: 10px;
  overflow: auto;
  max-height: 320px;
  font-family: var(--mono);
  font-size: 0.8rem;
  white-space: pre-wrap;
}

.report-grid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 1rem;
}
@media (max-width: 800px) {
  .report-grid { grid-template-columns: 1fr; }
}
.report-card {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 12px;
  padding: 1rem 1.1rem;
}
.report-card ul { list-style: none; padding: 0; margin: 0; }
.report-card li {
  display: flex;
  flex-wrap: wrap;
  align-items: baseline;
  gap: 0.35rem;
  padding: 0.4rem 0;
  border-bottom: 1px solid #eef2ef;
  font-size: 0.92rem;
}

.file-list { margin-top: 0.35rem; }
.file-row {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 5.5rem 2.25rem;
  column-gap: 0.75rem;
  align-items: center;
  padding: 0.38rem 0;
  border-bottom: 1px solid #eef2ef;
  font-size: 0.92rem;
}
.file-row-header {
  font-size: 0.72rem;
  font-weight: 600;
  letter-spacing: 0.04em;
  border-bottom: 1px solid var(--line);
  padding-bottom: 0.3rem;
  margin-bottom: 0.1rem;
}
.file-row-name {
  min-width: 0;
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}
.file-row-name a { text-decoration: none; }
.file-row-name a:hover { text-decoration: underline; }
.file-row-name code {
  font-size: 0.85em;
  background: transparent;
  padding: 0;
}
.file-row-size {
  text-align: right;
  font-family: var(--mono);
  font-size: 0.8rem;
  white-space: nowrap;
}
.file-row-dl {
  text-align: center;
}
.file-row-dl .tiny { margin-left: 0; }
.file-list-empty { margin: 0.5rem 0 0; font-size: 0.92rem; }

.qc-frame {
  width: 100%;
  min-height: 80vh;
  border: 1px solid var(--line);
  border-radius: 10px;
  background: #fff;
}
.table-scroll { overflow: auto; max-height: 70vh; border: 1px solid var(--line); border-radius: 10px; }
table.data th, table.data td { white-space: nowrap; font-size: 0.8rem; }

.summary-section { margin: 1.5rem 0 2rem; }
.summary-table th, .summary-table td { white-space: nowrap; vertical-align: middle; }
.summary-table .row-warn { background: #fff8f4; }
.qc-cells { display: flex; flex-wrap: wrap; gap: 0.35rem; align-items: center; }
.qc-pill {
  font-family: var(--mono);
  font-size: 0.72rem;
  border-radius: 999px;
  padding: 0.12rem 0.45rem;
  border: 1px solid var(--line);
  background: #f5f7f6;
}
.qc-pass { background: #e5f6ec; color: var(--ok); border-color: #b7dfc4; }
.qc-warn { background: #fff1e8; color: var(--warn); border-color: #efc2a5; }
.qc-fail { background: #fde8e8; color: var(--fail); border-color: #f0b4b4; }
.qc-lane {
  flex: 0 0 1.6rem;
  color: var(--muted);
  font-size: 0.78rem;
  font-weight: 600;
}
.qc-tally {
  margin-left: auto;
  font-family: var(--mono);
  font-size: 0.72rem;
  letter-spacing: 0.02em;
  padding: 0.08rem 0.4rem;
  border-radius: 6px;
  background: #f4f6f5;
  color: var(--muted);
  border: 1px solid #e3eae6;
}
.qc-n-sep { color: #b7c4be; }
.qc-n-pass { color: var(--ok); }
.qc-n-warn { color: #b56a38; }
.qc-n-fail { color: #a45a5a; }
.tiny-hint { font-size: 0.7rem; margin-left: 0.2rem; }

.sample-sections { margin: 0 0 2rem; }
.sample-block {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 12px;
  padding: 0.75rem 1rem 1rem;
  margin: 0.75rem 0;
}
.sample-block > summary {
  cursor: pointer;
  display: flex;
  flex-wrap: wrap;
  gap: 0.75rem;
  align-items: baseline;
  list-style: none;
}
.sample-block > summary::-webkit-details-marker { display: none; }
.sample-grid {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 1rem;
  margin-top: 0.85rem;
}
.sample-grid h3 { font-size: 0.9rem; margin: 0 0 0.4rem; color: var(--muted); }
.sample-grid ul { list-style: none; padding: 0; margin: 0; }
.sample-grid li {
  padding: 0.3rem 0;
  border-bottom: 1px solid #eef2ef;
  font-size: 0.88rem;
  display: flex;
  flex-wrap: wrap;
  gap: 0.35rem;
  align-items: baseline;
}
@media (max-width: 900px) {
  .sample-grid { grid-template-columns: 1fr; }
}

.deg-stats-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(9rem, 1fr));
  gap: 0.65rem;
  margin: 1rem 0 1.25rem;
}
.stat-card {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 0.65rem 0.85rem;
  display: flex;
  flex-direction: column;
  gap: 0.2rem;
}
.stat-label { font-size: 0.78rem; color: var(--muted); }
.stat-value { font-family: var(--mono); font-size: 1.15rem; font-weight: 600; }
.stat-up { border-color: #efb09a; background: #fff5f0; }
.stat-down { border-color: #a8c8e8; background: #f0f6fc; }
.stat-up .stat-value { color: #b84a28; }
.stat-down .stat-value { color: #3a6ea8; }

.plot-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 1rem;
  margin: 0.75rem 0 1rem;
}
.plot-grid-compact {
  grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
}
@media (max-width: 800px) {
  .plot-grid { grid-template-columns: 1fr; }
}
.plot-figure {
  margin: 0;
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 0.5rem;
  text-align: center;
}
.plot-figure img {
  max-width: 100%;
  height: auto;
  border-radius: 6px;
}
.plot-figure figcaption {
  margin-top: 0.35rem;
  font-size: 0.78rem;
  color: var(--muted);
}
.deg-up { color: #b84a28; font-weight: 600; }
.deg-down { color: #3a6ea8; font-weight: 600; }
.deg-direction-hint { margin: -0.5rem 0 1rem; }
.gene-name-cell {
  max-width: 16rem;
  white-space: nowrap;
  overflow: hidden;
  text-overflow: ellipsis;
}
.comp-section { margin-top: 2rem; padding-top: 0.5rem; border-top: 2px solid var(--line); }
.geneset-list .sample-block { margin: 0.5rem 0; }

.alert-info {
  background: #eef6fb;
  border-color: #b8d9eb;
  color: #1a4a66;
}
.report-phase {
  margin-top: 2rem;
  padding-top: 1.25rem;
  border-top: 3px solid var(--line);
}
.report-phase-downstream {
  border-top-color: #7eb8d4;
}
.report-phase > h2 {
  margin-bottom: 0.35rem;
}
.demo-links { margin-top: 0.5rem; font-size: 0.92rem; }
.report-block {
  margin-top: 2rem;
  padding-top: 1.25rem;
  border-top: 2px solid var(--line);
}
.report-block-downstream { border-top-color: #7eb8d4; }
.report-block > h3 { margin-bottom: 0.35rem; }
.comp-list-inline { margin: 0 0 1rem; font-size: 0.92rem; }

.design-form { margin-top: 0.75rem; }
.design-table input[type="text"] {
  font: inherit;
  width: 12rem;
  max-width: 100%;
  padding: 0.35rem 0.5rem;
  border: 1px solid var(--line);
  border-radius: 8px;
}
.comp-row {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: 0.45rem;
  margin: 0.4rem 0;
}
.comp-row select {
  font: inherit;
  width: 10rem;
  padding: 0.35rem 0.5rem;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fff;
}